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【Research Achievement】 A new research paper has been published in Crystal Growth & Design

A new research paper by Dr. Keiyo Nakai et al. has been published in the academic journal “Crystal Growth & Design of the American Chemical Society.

Journal: 　      Crystal Growth & Design (Published online 16 December 2024)

URL: 　　          https://doi.org/10.1021/acs.cgd.4c01421

DOI: 　　　      10.1021/acs.cgd.4c01421

Title: 　             Detection of Hydrogen Atoms Using Only 3D ED / MicroED and Contribution to Structure Determining Salts or Cocrystals

Authors: 　　  ¹Keiyo Nakai*, ¹Kuniyoshi Miki, ²Takashi Kikuchi, ¹Mitsuhisa Yamano

Affiliation:　   ¹SPERA PHARMA, Inc.　²Rigaku Corporation

Summary:

In recent years, structural analysis using 3D ED / MicroED with electron beams has attracted worldwide attention. 3D ED / MicroED allows visual identification of the position of hydrogen atoms, which is relatively difficult to identify using single crystal X-ray structure analysis. Identifying the positions of hydrogen atoms leads to interesting structure determination, which is beneficial for drug discovery research, such as determining whether the drug is a salt or co-crystal. In this study, the authors have achieved “direct” salt/cocrystal determinations for three well-known APIs using 3D ED / MicroED technology. These APIs were previously determined by “indirect” methods about salts or co-crystals. SPERA PHARMA is currently receiving numerous requests for 3D ED / MicroED measurements and continues to provide solutions to these challenges.

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